Polymer-based drug delivery systems
for biological molecules
Stem cell engineering and therapy
Solubilization of poorly water soluble drugs
학력
Ph.D. KAIST (2003)
약력/경력
2007~ : Assistant and Associate Professor, Sungkyunkwan University
2004~2007 : Postdoctoral Research Associate, University of Utah
2003~2004 : Postdoctoral Fellow, KAIST
학술지 논문
(2023)
Alveolar macrophage phagocytosis-evading inhaled microgels incorporating nintedanib-PLGA nanoparticles and pirfenidone-liposomes for improved treatment of pulmonary fibrosis.
BIOACTIVE MATERIALS.
33,
1
(2023)
Highly Prolonged Release of the Cancer Vaccine and Immunomodulator via a Two-Layer Biodegradable Microneedle for Prophylactic Treatment of Metastatic Cancer.
BIOMACROMOLECULES.
24,
3
(2023)
Chemoattractant releasing microneedles for enhanced DNA vaccination.
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY.
117,
1
(2022)
Delivery of self-replicating messenger RNA into the brain for the treatment of ischemic stroke.
JOURNAL OF CONTROLLED RELEASE.
350,
(2022)
Nanomicelle-generating Microneedles Loaded With Tranilast for Treatment of Hypertrophic Scars in a Rabbit Model.
IN VIVO.
36,
4
(2022)
Microneedle-Directed Drug Delivery to Tumor-Draining Lymph Node for Synergistic Combination Chemoimmunotherapy for Metastatic Cancer.
ADVANCED THERAPEUTICS.
5,
4
(2022)
Sustained Exosome-Guided Macrophage Polarization Using Hydrolytically Degradable PEG Hydrogels for Cutaneous Wound Healing: Identification of Key Proteins and MiRNAs, and Sustained Release Formulation.
SMALL.
18,
15
(2021)
Separable Microneedle Patch to Protect and Deliver DNA Nanovaccines Against COVID-19.
ACS NANO.
15,
9
(2021)
Hyaluronic Acid Coating on Hydrophobic Tracheal Scaffold Enhances Mesenchymal Stem Cell Adhesion and Tracheal Regeneration.
TISSUE ENGINEERING AND REGENERATIVE MEDICINE.
18,
2
(2021)
Toxico-metabolomics study of a deep eutectic solvent comprising choline chloride and urea suggestsin vivotoxicity involving oxidative stress and ammonia stress.
GREEN CHEMISTRY.
23,
3
(2021)
Human Ferritin Platform and Its Optimized Structures to Enhance Anti-Cancer Immunity.
ADVANCED THERAPEUTICS.
4,
2
(2020)
Enhanced Cancer DNA Vaccine via Direct Transfection to Host Dendritic Cells Recruited in Injectable Scaffolds.
ACS NANO.
14,
9
(2020)
Insights into the Vastly Different Effects of Eutectic Solvents on the Stability of Phenolic Compounds.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS.
11,
13
(2020)
Messenger RNA/polymeric carrier nanoparticles for delivery of heme oxygenase-1 gene in the post-ischemic brain.
BIOMATERIALS SCIENCE.
8,
11
(2020)
Development of microRNA-21 mimic nanocarriers for the treatment of cutaneous wounds.
THERANOSTICS.
10,
7
(2020)
Degradation-regulated architecture of injectable smart hydrogels enhances humoral immune response and potentiates antitumor activity in human lung carcinoma.
BIOMATERIALS.
230,
(2019)
Simultaneous delivery of DNA vaccine and hydrophobic adjuvant using reducible polyethylenimine-functionalized graphene oxide for activation of dendritic cells.
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY.
80,
1
(2019)
Effective systemic siRNA delivery using dual-layer protected long-circulating nanohydrogel containing an inorganic core.
BIOMATERIALS SCIENCE.
7,
8
(2019)
Enhanced Transfection of Human Mesenchymal Stem Cells Using a Hyaluronic Acid/Calcium Phosphate Hybrid Gene Delivery System.
POLYMERS.
11,
5
단행본
(2009)
약제학요점.
신일북스.
공동
(2009)
생체재료학.
자유아카데미.
공동
(2009)
제제학 (의약품제형과 약물전달시스템).
도서출판 신일북스.
공동
특허/프로그램
체세포 직접교차분화 유도 나노입자의 제조방법 및 이의 용도(A Method for preparing nanoparticles inducing direct conversion from somatic cells and use thereof).
10-1960-1700000.
20190313.
대한민국
자가 조립 나노입자 방출형 용해성 마이크로니들 구조체 및 그 제조방법(Dissolvable microneedles structure releasing self-assembled nanoparticles and method for preparing same).
10-1956-4440000.
20190304.
대한민국
카테콜기를 포함하는 유기화합물로 개질된 친수성 고분자를 이용한 칼슘 포스페이트 나노 복합체 및 그 제조방법.
10-2014-0108520.
20171221.
대한민국
생체모방물질을 이용한 칼슘포스페이트 나노입자 제제.
10-2013-0007675.
20141120.
대한민국
카데콜기를 포함하는 유기화합물로 개질된 친수성 고분자를 이용한 칼슘 포스페이트 나노 복합체 및 그 제조방법.
10-2013-0007675.
20141120.
대한민국
수난용성 약물을 내부에 포함하는 알부민 나노입자 제조방법.
10-2012-0009253 .
20141022.
대한민국
고효율 유전자 전달을 위한 항산화성 고분자 미셀제제.
10-1023-0079604.
20140225.
대한민국
미셀을 주형으로 이용한 금 나노입자의 제조방법(A method for manufacturing dendritic gold nanoparticles using antioxidative micelles as a template).
10-1362549-0000.
20140206.
대한민국
폴리에틸렌이민 및 담즙산으로 구성되는 세포막융합활성을 지닌 양친성 고분자 회합체.
10-1128108.
20120312.
대한민국
학술회의논문
(7013)
Reduced cellular oxidative stress by antioxidative polymeric micelles directed to enhanced gene transfection.
The 7th World Congress on Biomimetics, Artificial Muscles and Nano-Bio.
대한민국
(2023)
Tailoring Liposomal Membrane Elasticity for Enhanced Biodistribution and Anti-Imflammatory Responses in Systemic Rheumatoid Arthritis Treatment.
ESB2023.
스위스
(2020)
Repositioning dihydroergotamine on sepsis with self-assembled PEGylated human serum albumin nanocarrier.
2020년 한국생체재료학회 추계학술대회.
대한민국
(2020)
Hyaluronic acid / calcium phosphate hybrid gene delivery system promotes osteogenic differentiation of human mesenchymal stem cells.
2020 한국공업화학회 학술대회.
대한민국
(2020)
Improvement of gene silencing and development of siRNA delivery by dendritic gold nanoparticle.
2020 한국공업화학회 학술대회.
대한민국
(2020)
Suppression of tumor growth via systemic siRNA delivery with bioreducible bile acid-conjugated PEI.
2020 한국공업화학회 학술대회.
대한민국
(2020)
Enhanced cancer chemo-immunotherapy using nanomicelles-generating microneedles containing paclitaxel and TLR7/8 agonist.
2020 한국생물공학회 추계학술대회 및 국제심포지움.
대한민국
(2020)
Enhanced systemic siRNA delivery to solid tumors by reducible bile acid conjugate polyethylenimine.
2020 한국생물공학회 추계학술대회 및 국제심포지움.
대한민국
(2020)
Repositioning dihydroergotamine on sepsis with self-assembled PEGylated human serum albumin nanocarrier.
2020 한국생물공학회 추계학술대회 및 국제심포지움.
대한민국
(2020)
Hyaluronic acid / calcium phosphate hybrid gene delivery system promotes osteogenic differentiation of human mesenchymal stem cells.
2020 한국생물공학회 춘계학술대회 및 국제심포지움.
대한민국
(2020)
Inhibition of metastatic melanoma through nano-micelle generating microneedles including doxorubicin.
2020 한국생물공학회 춘계학술대회 및 국제심포지움.
대한민국
(2019)
Therapeutic cancer vaccination using nanoparticle-releasing microneedles.
IEEE International Conference on Nano/Molecular Medicine and Engineering.
대한민국
(2019)
Enhanced cancer immunotherapy using nanomicelle generating microneedles containing paclitaxel and TLR7/8 agonist.
한국약제학회 국제학술대회.
대한민국
(2019)
Rivoceranib drug re-positioning: developing new uses for anti-neovascularization via the regulation of tyrosine kinase signaling.
한국약제학회 국제학술회의.
대한민국
(2019)
Stabilized nanominerals for the targeted delivery of biomolecules.
한국공업화학회 추계학술대회.
대한민국
(2018)
GO nanoflakes fuctionalized with catechol-derivatized cationic polymer for efficient siRNA delivery.
2018 한국생체재료학회 추계학술대회 및 총회.
대한민국
(2018)
Intradermal co-delivery of plasmid DNA and hydrophobic adjuvant via dissolving microneedles for enhanced cancer theraphy.
2018 한국생체재료학회 추계학술대회 및 총회.
대한민국
(2018)
hMSC osteogenic differentiation using cap/catechol-HA gene delivery vector.
2018 한국생체재료학회 추계학술대회 및 총회.
대한민국
(2018)
Oral delivery of superoxide dismutase to treat acetaminophene-induced hepatotoxicity and liver disease using deoxycholic aicd-modified polyethylenimine.
2018 한국공업화학회 춘계 총회 및 학술대회.
대한민국
(2018)
hMSC using CaP/dopa/HA gene delivery for inducing osteogenic differentiation.
2018 한국공업화학회 춘계 총회 및 학술대회.
대한민국
